Flannel fabric is tough on needles and rotary cutter blades, therefore always start with fresh ones. If you are sewing a large quilt, you may need to change needles and blades once or twice during your project. A quilt or project with complex patterns made of many smaller pieces is not recommended for this fabric because the same napping, which makes it soft and fuzzy also causes bulkier seams than traditional quilting cottons. Therefore, it is best to choose patterns created from larger pieces.
Smaller stitches can stretch your fabric, therefore it is recommended to quilt with a longer stitch (3 to 3.5). If hand quilting, do not use small, fine stitches, because not only will the fabric thickness cause needles to bend if using a classic rocking quilt stitch technique, but the fabric thickness will also hurt your hands. If you need to un-sew, do so calmly and carefully. Pulling and tugging can stretch this fabric out of shape.
If binding the edges, use larger binding strips at least 2.5 inches wide to compensate for the flannel fabric thickness.
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